基本简介

职称：副教授, 博士生导师

学位：博士

毕业学校：清华大学、美国Lehigh大学

主要兼职：中国生物材料学会神经修复材料分会委员

广东省软组织生物制造工程实验室副主任

电子邮件：baiy28@mail.sysu.edu.cn

学历

本科：清华大学

硕士：清华大学

博士：美国Lehigh大学

学术经历

博士后：美国马萨诸塞州大学 (UMass Amherst) 高分子国家实验室

学科方向

所在学科：高分子材料与工程

研究方向：生物医用高分子材料

研究兴趣：组织工程与再生医学、生物医用高分子材料的合成与加工、先进生物制造技术（生物3D打印、静电纺丝等）

学术业绩

本课题组长期从事天然来源脱细胞基质生物材料的基础研究与临床转化，尤其是神经系统损伤后的再生与修复治疗。详细分析了不同组织来源脱细胞基质之间的成分差异、参与细胞调控的关键要素与潜在机制，建立了研究这类材料组织特异性的普适方法；结合3D打印、静电纺丝等先进制造技术对脱细胞基质材料进行深加工，重塑生物活性支架的微纳拓扑结构，拓展了这类材料的应用范围。应邀在全国生物材料大会神经修复分会做主题报告和主持人。曾担任广东省珠江人才计划引进创新创业团队核心成员。

代表论著

1. C.L. Zhao#, Z.J. Wu#, H.Y. Chu, T. Wang, S. Qiu, J. Zhou, Q.T. Zhu, X.L. Liu, D.P. Quan, Y. Bai*. Thiol-Rich Multifunctional Macromolecular Crosslinker for Gelatin-Norbornene-Based Bioprinting, Biomacromolecules 2021, 22, 2729 - 2739.

2. Y.W. Xu, J. Zhou, C.C. Liu, S. Zhang, F.L. Gao, W.J. Guo, X.M. Sun, C. Zhang, H.Y. Li, Z.L. Rao, S. Qiu, Q.T. Zhu, X.L. Liu, X.D. Guo, Z.W. Shao, Y. Bai*, X. Zhang*, D.P. Quan*. Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury. Biomaterials 2021, 268, 120596. (ESI高被引论文)

3. C.S. Zheng#, Z.H. Yang#, S.H. Chen#, F. Zhang, Z.L. Rao, C.L. Zhao, D.P. Quan, Y. Bai*, J. Shen*. Nanofibrous nerve guidance conduits decorated with decellularized matrix hydrogel facilitate peripheral nerve injury repair. Theranostics 2021, 11(6), 2917 - 2931.

4. Z.L. Rao#, T. Lin#, S. Qiu, J. Zhou, S. Liu, S.H. Chen, T. Wang, X.L. Liu, Q.T. Zhu, Y. Bai*, D.P. Quan*. Decellularized nerve matrix hydrogel scaffolds with longitudinally oriented and size-tunable microchannels for peripheral nerve regeneration. Mater. Sci. Eng. C 2021,120, 111791.

5. X.M. Sun, C. Zhang, J.H. Xu, H. Zhai, S. Liu, Y.W. Xu, Y. Hu, H.Q. Long*, Y. Bai*, D.P. Quan*.  Neurotrophin-3-Loaded Multichannel Nanofibrous Scaffolds Promoted Anti-Inflammation, Neuronal Differentiation, and Functional Recovery after Spinal Cord Injury. ACS Biomater. Sci. Eng. 2020, 6, 1228 - 1238.

6. Y. Bai, L.M. He, X. Lou, D.P. Quan*. Electrospun bioactive composites for neural tissue engineering applications. Electrospun Polymers and Composites: Ultrafine Materials, High Performance Fibers and Wearables 2020, Elsevier.

7. S.H. Chen, Z.Y. Du, J. Zou, S. Qiu, Z.L. Rao, S. Liu, X.M. Sun, Y.W. Xu, Q.T. Zhu, X.L. Liu, H.-Q. Mao, Y. Bai*, D.P. Quan*.  Promoting Neurite Growth and Schwann Cell Migration by the Harnessing Decellularized Nerve Matrix onto Nanofibrous Guidance. ACS Appl. Mater. Interfaces 2019, 11, 17167 − 17176.

8. R.L. Deng, Z.L. Luo, Z.L. Rao, Z.D. Lin, S.H. Chen, J. Zhou, Q.T. Zhu, X.L. Liu, Y. Bai*, D.P. Quan*. Decellularized Extracellular Matrix Containing Electrospun Fibers for Nerve Regeneration: A Comparison Between Core–Shell Structured and Preblended Composites. Adv. Fiber Mater. 2022, DOI: 10.1007/s42765-021 -00124-5.

9. Y. Bai, C-C. Chang, U. Chaudhury, I. Bolukbasi, A.J. Crosby, T. Emrick. Functional Droplets that Recognize, Collect, and Transport Debris on Surfaces, Sci. Adv. 2016, 2(10), e1601462.

10. Y. Bai, C-C. Chang, X.J. Zhao, A. Ribbe, I. Bolukbasi, M.J. Szyndler, A.J. Crosby, T. Emrick. Mechanical Restoration of Damaged Polymer Films by “Repair-and-go”, Adv. Fun. Mater. 2016, 26, 857 – 863.