基本简介
职称：副教授，博士生导师
学位：博士
毕业学校：复旦大学
电子邮箱：liuzhj9@mail.sysu.edu.cn
通讯地址：广州市番禺区大学城外环东路132号化学材料综合楼，邮编510006
学历
2011-2016年，复旦大学高分子科学系，博士学位
2007-2011年，湘潭大学化学学院，学士学位
学术经历
2019年-至今，中山大学材料科学与工程学院，副教授
2016-2019年，中山大学材料科学与工程学院，特聘副研究员
学科方向
所在学科：材料科学与工程，高分子材料与工程
研究方向：医用材料化学，生物医用有机高分子材料
研究兴趣：生物大分子药物递送系统的设计、制备及应用
学术业绩
以临床需求为导向，发展先进药物递送系统技术。构建了基于Ugi-4CR反应的模块化组合化学方法用于开发蛋白质、核酸药物递送载体；提出了载体多维设计理念以及创新入胞机制，发展了高效安全的脂质纳米粒（LNP）技术，实现了肝、脾、肺以及特定细胞的靶向mRNA递送；提出了一种高效连续的闪速纳米复合可控制备方法，突破了生物大分子纳米药物规模制备的应用瓶颈。在国际权威学术期刊发表论文50余篇，其中以通讯作者在Angewandte Chemie International Edition、Advanced Materials、ACS Central Science、Biomaterials、Journal of controlled release等期刊发表论文20余篇；获中国发明专利授权11项，申请美国发明专利4项、欧洲和日本发明专利各2项；主持国家及地区科研项目4项，作为核心骨干参与国际地区合作项目1项和广东省重大基础研究项目1项；受邀在国际纳米药物会议、纳米医学交叉创新论坛、广州分子工程国际峰会等作学术报告。
欢迎联系
本课题组常年招聘具有化学、材料、药学、医学、人工智能等学科研究背景的博士后来组进行合作研究；欢迎志同道合的广大青年学子报考课题组的硕士和博士研究生。请通过本人电子邮箱联系。
荣誉获奖
Wiley China Excellent Author Program（2024）
中山大学优秀辅导员（2022）
中山大学材料科学与工程学院青年教师授课大赛三等奖（2021）
代表论著
1. Ge, X.#; He, Z.#; Yang, H.; Pan, X.; Yan, L.; Shi, Y.; Chen, Y.*; Liu, Z.* Impact of tail unsaturation in ionizable lipids on mRNA delivery efficiency and immunogenicity of lipid nanoparticles. Journal of Controlled Release 2025, 384, 113906-113906.
2. Yang, H.; Gao, Z.; Zhou, Y.; Ge, X.; Pan, X.; Li, J.; Zhang, Z.; Jin, X.; Liu, G.; He, Z.; Liu, H.*; Liu, Z.*; Liu, L.*; Chen, Y.* Tertiary amine N-oxide zwitterionic lipids facilitate muscle-selective mRNA vaccine delivery for enhancing cDC1-mediated antitumor efficacy. Journal of Controlled Release 2025, 384, 113892-113892.
3. Gao, Z.; Yang, H.; He, Z.; Zhou, Y.; Ge, X.; Liu, H.; Yan, Z.; Wang, H.; Wei, L.; Qiao, D.*; Liu, Z.*; Zhu, T.*; Liu, L.*; Chen, Y.* Cost-effective yet high-performance ionizable lipids for mRNA-lipid nanoparticle vaccines. Biomaterials 2025, 323. 123421.
4. He, Z.#; Le, Z.#; Liu, Z.*; Chen, Y.* Multicomponent reaction-based combinatorial chemistry for accelerating the discovery of therapeutic protein and nucleic acid delivery materials. NPG Asia Materials 2025, 17. 14.
5. Zeng, G.#; He, Z.#; Yang, H.; Gao, Z.; Ge, X.; Liu, L.; Liu, Z.*; Chen, Y.* Cationic Lipid Pairs Enhance Liver-to-Lung Tropism of Lipid Nanoparticles for In Vivo mRNA Delivery. ACS Applied Materials & Interfaces 2024, 16, 25698-25709.
6. Le, Z.#; Ramos, M. C.#; Shou, Y.; Li, R. R.; Cheng, H. S.; Jang, C. J. M.; Liu, L.; Xue, C.; Li, X.; Liu, H.; Lim, C. T.; Tan, N. S.; White, A. D.; Charles, C. J.; Chen, Y.; Liu, Z.*; Tay, A.* Bioactive sucralfate-based microneedles promote wound healing through reprogramming macrophages and protecting endogenous growth factors. Biomaterials 2024, 311. 122700.
7. Le, Z.#; Qian, J.#; Chen, H.#; He, Z.; Tan, R.; Liu, H.; Wen, Z.; Shi, Y.; Liu, Z.*; Chen, Y.* A versatile gemini amphiphile-based platform with STING-activating properties for efficient gene delivery into dendritic cells. Chemical Engineering Journal 2024, 497. 154513.
8. Shou, Y.#; Le, Z.#; Cheng, H. S.; Liu, Q.; Ng, Y. Z.; Becker, D. L.; Li, X.; Liu, L.; Xue, C.; Yeo, N. J. Y.; Tan, R.; Low, J.; Kumar, A. R. K.; Wu, K. Z.; Li, H.; Cheung, C.; Lim, C. T.; Tan, N. S.; Chen, Y.; Liu, Z.*; Tay, A.* Mechano-Activated Cell Therapy for Accelerated Diabetic Wound Healing. Advanced Materials 2023, 35. 2304638.
9. Le, Z.#; Pan, Q.#; He, Z.; Liu, H.; Shi, Y.; Liu, L.; Liu, Z.*; Ping, Y.*; Chen, Y.* Direct Cytosolic Delivery of Proteins and CRISPR-Cas9 Genome Editing by Gemini Amphiphiles via Non-Endocytic Translocation Pathways. ACS Central Science 2023, 9, 1313-1326.
10. He, Z.; Le, Z.; Shi, Y.; Liu, L.; Liu, Z.*; Chen, Y.* A Multidimensional Approach to Modulating Ionizable Lipids for High-Performing and Organ-Selective mRNA Delivery. Angewandte Chemie International Edition 2023, 62. e202310401.
11. Chen, S.#; Le, Z.#; Gu, J.; Liu, L.; Liu, Z.*; Chen, Y.* Exploring the Effect of Amphiphile Architecture on Intracellular Protein Delivery Capacity: Dimeric versus Trimeric Amphiphiles. ACS Applied Materials & Interfaces 2023, 15, 26328-26339.
12. Le, Z.; He, Z.; Liu, H.; Liu, L.; Liu, Z.*; Chen, Y.* Antioxidant Enzymes Sequestered within Lipid-Polymer Hybrid Nanoparticles for the Local Treatment of Inflammatory Bowel Disease. ACS Applied Materials & Interfaces 2021, 13, 55966-55977.
13. Sun, P.; Huang, T.; Wang, X.; Wang, G.; Liu, Z.*; Chen, G.; Fan, Q.* Dynamic-Covalent Hydrogel with NIR-Triggered Drug Delivery for Localized Chemo-Photothermal Combination Therapy. Biomacromolecules 2020, 21, 556-565.
14. Le, Z.; Xiao, T.; Liu, Z.*; Liu, X.; Liu, H.; Liu, L.; Chen, Y.* Combinatorial synthesis of redox-responsive cationic polypeptoids for intracellular protein delivery application.Science China Chemistry 2020, 63, 1619-1625.
15. Sun, L.; Liu, Z.*; Tian, H.; Le, Z.; Liu, L.; Leong, K. W.; Mao, H.-Q.; Chen, Y.* Scalable Manufacturing of Enteric Encapsulation Systems for Site Specific Oral Insulin Delivery. Biomacromolecules 2019, 20, 528-538.
16. Tian, H.; He, Z.; Sun, C.; Yang, C.; Zhao, P.; Liu, L.; Leong, K. W.; Mao, H.-Q.*; Liu, Z.*; Chen, Y.* Uniform Core-Shell Nanoparticles with Thiolated Hyaluronic Acid Coating to Enhance Oral Delivery of Insulin. Advanced Healthcare Materials 2018, 7. 1800285.
17. Le, Z.; Chen, Y.; Han, H.; Tian, H.; Zhao, P.; Yang, C.; He, Z.; Liu, L.; Leong, K. W.; Mao, H.-Q.; Liu, Z.*; Chen, Y.* Hydrogen-Bonded Tannic Acid-Based Anticancer Nanoparticle for Enhancement of Oral Chemotherapy. ACS Applied Materials & Interfaces 2018, 10, 42186-42197.
