柯卓锋

个人基本简介: 

柯卓锋 (Zhuofeng Ke)
理学博士。中山大学“百人计划”副教授,博士生导师。
电话:+86-20-84113071 邮编:510275
邮箱:kezhf3@mail.sysu.edu.cn
通讯地址:广州市新港西路135号中山大学化学与化学工程学院丰盛堂C910

主要经历: 

2016至今          中山大学,材料科学与工程学院,副教授/博导
2012-2016      中山大学,化学院,副教授/博导
2009-2012      日本京都大学,福井谦一FIFC研究员

2005-2009      中山大学/美国北德克萨斯大学,物理化学,联合培养博士
2002-2005      中山大学,高分子化学与物理,硕士
1998-2002      中山大学,化学系,本科

学科方向: 

1. 反应机理与催化材料设计
2. 催化新方法与可再生能源
3. 催化合成与高分子新材料

课题组招收有机化学、高分子合成化学、理论计算化学等相关背景的博士后和专职科研人员

荣誉获奖: 

广东省自然科学杰出青年(2015)
广东特支计划百千万工程青年拔尖人才(2014)
福井谦一博士后特别研究员基金奖励(2009-2012)
国家留学基金奖励(2007)

主要兼职: 

国家自然科学基金面上项目,2017.01-2020.12,主持
国家自然科学基金面上项目,2015.01-2018.12,主持
国家自然科学基金青年项目,2013.01-2015.12,主持
广东省自然科学杰出青年基金,2015.08-2019.08,主持
广东特支计划百千万工程青年拔尖人才,2015.12-2018.12,主持
中山大学“百人计划”启动项目,2012.4-2013.12,主持

代表论著: 

47. Hou, C., Jiang, J., Li, Y., Zhao, C.*, Ke, Zhuofeng*. When Bifunctional Catalyst Encounters Dual MLC Modes: DFT Study on the Mechanistic Preference in Ru-PNNH Pincer Complex Catalyzed Dehydrogenative Coupling Reaction. ACS Catal. 2017, 7(1), 786–795.

46. Xiao X., Hou C., Zhang Z., Ke Zhuofeng*, Lan J., Jiang H., Zeng W.* Iridium(III)-Catalyzed Regioselective Intermolecular Unactivated Secondary Csp3-H Bond Amidation. Angew. Chem., Int. Ed. 2016, 128, 12076–12080.

45. Li, Y., Hou, C., Jiang, J., Zhang, Z., Zhao, C., Page, A., Ke, Zhuofeng*. General H2 Activation Modes for Lewis Acid-Transition Metal Bifunctional Catalysts. ACS Catal. 2016, 6, 1655–1662.

44. Wu, J.J, Li, Y., Zhou, H.Y., Wen, A.H., Lun, C.C., Yao, S.Y., Ke, Zhuofeng*, Ye, B.H.*. Copper-Catalyzed Carbamoylation of Terminal Alkynes with Formamides via Cross-Dehydrogenative Coupling. ACS Catal. 2016, 6, 1263–1267.

43. Hou C., Zhang Z., Zhao, C.*, Ke Zhuofeng*. DFT Study of Acceptorless Alcohol Dehydrogenation Mediated by Ruthenium Pincer Complexes: Ligand Tautomerization Governing Metal Ligand Cooperation. Inorg. Chem. 2016, 55, 6539−6551.

42. Wei J., Jiang J., Xiao X., Lin D.G.*, Deng Y., Ke, Zhuofeng*, Jiang H.F., Zeng, W*. Copper-Catalyzed Regioselective C-H Sulfonylation of 8-Aminoquinolines. J. Org. Chem. 2016, 81 (3), 946–955.

41. Ouyang, J.-S., Li, Y.-F., Shen D.-S., Ke, Zhuofeng*, Liu F.-S.* Bulky α-diimine palladium complexes: highly efficient for direct C–H bond arylation of heteroarenes under aerobic conditions dimine arylation. Dalton Trans. 2016, 45, 14919−14927.

40. He, X.-X., Li Y., Ma B.-B., Ke Zhuofeng*, Liu F.-S.* Sterically Encumbered Tetraarylimidazolium Carbene Pd-PEPPSI Complexes: Highly Efficient Direct Arylation of Imidazoles with Aryl Bromides under Aerobic Conditions. Organometallics, 2016, 35, 2655–2663.

39. Peng, C.-C., Li, Z., Deng, L.-Q., Ke, Zhuo-Feng, Chen, W.-H. 2,6-Bis(benzimidazol-2-yl)pyridine as a potent transmembrane anion transporter. Bioorg. Med. Chem. Lett. 2016, 26, 2442−2445.

38. Xu, H., Zhang, X., Ke, Zhuofeng*, Zhao, C.* A Theoretical Study of Dirhodium-Catalyzed Intramolecular Aliphatic C?H Bond Amination of Aryl Azides. RSC Adv. 2016, 6, 29045–29053.

37. Xue, S.-S.; Zhao, M.; Ke, Zhuo-Feng; Cheng, B.-C.; Su, H.; Cao, Q.; Cao, Z.-K.; Wang, J.; Ji, L.-N.; Mao, Z.-W. Enantioselective Hydrolysis of Amino Acid Esters Promoted by Bis(β-cyclodextrin) Copper Complexes. Sci. Rep., 2016, 6, DOI: 10.1038/srep22080.

36. Jiang, J., Liu, Y., Hou, C., Li, Y., Luan, Z., Zhao C., and Ke, Zhuofeng*. Rationalization of the Selectivity between 1,3- and 1,2-Migration: DFT Study on Gold(I)-Catalyzed Propargylic Ester Rearrangement. Org. Biomol. Chem., 2016, 14, 3558–3563.

35. Luo, B.-T., Liu H., Lin Z.-J., Jiang, J., Sheng D.-S., Liu R.-Z., Ke, Zhuofeng*, Liu, F.-S.* Aerobic and Efficient Direct Arylation of Five-Membered Heteroarenes and Their Benzocondensed Derivatives with Aryl Bromides by Bulky α-Hydroxyimine Palladium Complexes. Organometallics, 2015, 34, 4881–4894.

34. Hou, C., Jiang, J., Li, Y., Zhang, Z., Zhao C.*, Ke, Zhuofeng*. Unusual Non-bifunctional Mechanism for Co-PNP Complex Catalyzed Transfer Hydrogenation Governed by the Electronic Configuration of Metal Center. Dalton Trans. 2015, 44, 16573–16585.

33. Chung, L. W., Sameera, W. M. C., Ramozzi, R., Page, A. J., Hatanaka, M., Petrova, G. P., Harris, T. V., Li X., Ke, Zhuofeng, Liu, F., Li, H.-B., Ding, L., Morokuma, K.* The ONIOM Method and Its Applications. Chem. Rev. 2015, 15, 5678–5796.

32. Xu, X.-Y., Li, J., Zhang, X., Xu, H., Ke, Zhuo-Feng*, Zhao, C.* Removal of NO with silicene: A DFT investigation. RSC Adv. 2015, 5, 22135–22147.

31. Jiang, J., Hou, C., Zhang S., Luan Z., Zhao, C., Ke, Zhuofeng.* The Effect of HSAB on Stereoselectivity: Copper and Gold Catalyzed 1,3-Phosphatyloxy and 1,3-Halogen Migration Relay to 1,3-Dienes. J. Org. Chem. 2015, 80 (3), 1661–1671.

30. Zhang, F., Fan, J., Yu, H., Ke, Zhuofeng, Nie, C., Kuang, D.*, Shago, G.*, Su C. Nonplanar Organic Sensitizers Featuring a Tetraphenylethene Structure and Double Electron-Withdrawing Anchoring Groups. J. Org. Chem. 2015, 80, 9034–9040.

29. Zhang, M., Zhang, M.-T., Hou, C., Ke, Zhuofeng*, Lu T.-B.* Homogeneous Electrocatalytic Water Oxidation at Neutral pH by a Robust Macrocyclic Nickel(II) Complex. Angew. Chem., Int. Ed. 2014, 53, 13042–13048. (Frontispiece Paper)

28. Hou, C., Jiang J., Zhang S., Wang G., Zhang Z., Ke, Zhuofeng*, Zhao C.* Hydrogenation of Carbon Dioxide Using Half-Sandwich Cobalt, Rhodium, and Iridium Complexes: DFT Study on the Mechanism and Metal Effect. ACS Catal. 2014, 4, 2990–2997.

27. Zhou, Y.G., Zhang, X.P., Liang, H.Y., Cao, Z.K., Zhao, X.Y., He, Y.W., Wang, S.L., Pang, J.Y., Zhou, Z.Y., Ke, Zhuofeng*, Qiu L.Q.* Enantioselective Synthesis of Axially Chiral Biaryl Monophosphine Oxides via Direct Asymmetric Suzuki Coupling and DFT Investigations of the Enantioselectivity. ACS Catal. 2014, 4, 1390–1397.

26. Petrova, G.P., Ke, Zhuofeng, Park S., Sugiyama H., Morokum K.* The origin of enantioselectivity for intramolecular Friedel–Crafts reaction catalyzed by supramolecular Cu/DNA catalyst complex. Chem. Phys. Lett. 2014, 600, 87–95.

25. Zhang, X., Ke, Zhuofeng, DeYonker N. J., Xu, H., Li Z.-F., Xu X., Zhang X., Su C.-Y., Phillips D. L., Zhao C.* Mechanism and Enantioselectivity of Dirhodium-Catalyzed Intramolecular C–H Amination of Sulfamate. J. Org. Chem. 2013, 78 (24), 12460–12468.

24. Liu, Y., Ma, L., Chen, W.-H.*, Park, H., Ke, Zhuofeng*, Wang, B*. Binding Mechanism and Synergetic Effects of Xanthone Derivatives as Noncompetitive α-Glucosidase Inhibitors: A Theoretical and Experimental Study. J. Phys. Chem. B 2013, 117 (43), 13464–13471.

23. Ye, R.-R., Ke, Zhuofeng, Tan, C.-P., He, L., Ji, L.-N. & Mao, Z.-W. Histone-Deacetylase-Targeted Fluorescent Ruthenium(II) Polypyridyl Complexes as Potent Anticancer Agents. Chem. Eur. J. 2013, 19 (31), 10160 –10169. (Cover Page)

22. Xu, H. Y., Zhang, X. T., Ke, Zhuofeng, Li, Z. F., Xu, X. Y., Su, C. Y., Phillips, D. L. & Zhao, C. Y. Density functional theory study of the mechanism of zinc carbenoid promoted cyclopropanation of allenamides. RSC Adv. 2013, 3, 17131–17142.

21. Ke, Zhuofeng, Abe, S., Ueno, T., & Morokuma, Keiji. Catalytic Mechanism in Artificial Metalloenzyme: QM/MM Study of Phenylacetylene Polymerization by Rhodium Complex Encapsulated in apo-Ferritin. J. Am. Chem. Soc. 2012, 134 (37), 15418–15429.

20. Ke, Zhuofeng, Abe, S., Ueno, T., & Morokuma, Keiji. Rh-catalyzed Polymerization of Phenylacetylene: Theoretical Studies of the Reaction Mechanism, Regioselectivity and Stereoregularity. J. Am. Chem. Soc. 2011, 133 (20), 7926–7941. (JACS beta Select issue 13)

19. Liu, Y., Ke, Zhuofeng, Liu, Shuwen, Chen, Wen-Hua, Jiang, Shibo; Jiang, Zhi-Hong. An Amphiphilic Conjugate Approach toward the Design and Synthesis of Betulinic Acid-Polyphenol Conjugates as Inhibitors of the HIV-1 gp41 Fusion Core Formation. ChemMedChem 2011, 6 (9), 1654–1664.

18. Gao, H., Ke, Zhuofeng, DeYonker N.J., Wang J., Xu H., Mao Z.-W., Phillips, D.L., Zhao C., Dinuclear Zn(II) Complex Catalyzed Phosphodiester Cleavage Proceeds via a Concerted Mechanism: A Density Functional Theory Study. J. Am. Chem. Soc. 2011, 133 (9), 2904–2915.

17. Ke, Zhuofeng & Cundari, T.R., Palladium-Catalyzed C-H Activation/C-N Bond Formation Reactions: DFT Study of Reaction Mechanisms and Reactive Intermediates. Organometallics 2010, 29 (4), 821–834. (Top10 Most Accessed Articles of Organometallics in 2010)

16. Lee, J.P., Ke, Zhuofeng, Ramirez, M.A., Gunnoe, T.B., Cundari, T.R., Boyle, P.D., & Petersen, J.L., Six-, Five-, and Four-Coordinate Ruthenium(II) Hydride Complexes Supported by N-Heterocyclic Carbene Ligands: Synthesis, Characterization, Fundamental Reactivity, and Catalytic Hydrogenation of Olefins, Aldehydes, and Ketones. Organometallics 2009, 28 (6), 1758–1775.

15. Guo, Z., Xue, J.D., Ke, Zhuofeng, Phillips, D.L., & Zhao, C.Y., Influence of Water Hydrogen Bonding on the Reactions of Arylnitrenium Ions With Guanosine: Hydrogen-Bonding Effects Can Favor Reaction at the C8 Site. J. Phys. Chem. B 2009, 113 (18), 6528–6532.

14. Foley, N.A., Lee, J.P., Ke, Zhuofeng, Gunnoe, T.B., & Cundari, T.R., Ru(II) Catalysts Supported by Hydridotris(pyrazolyl)borate for the Hydroarylation of Olefins: Reaction Scope, Mechanistic Studies, and Guides for the Development of Improved Catalysts. Acc. Chem. Res. 2009, 42 (5), 585–597.

13. Liu, Y., Ke, Zhuofeng, Cui, J.F., Chen, W.H., Ma, L., & Wang, B., Synthesis, inhibitory activities, and QSAR study of xanthone derivatives as alpha-glucosidase inhibitors. Bioorg. Med. Chem. 2008, 16 (15), 7185-7192.

12. Guo, Z., Ke, Zhuofeng, Phillips, D.L., & Zhao, C.Y., Intrinsic reaction coordinate analysis of the activation of CH4 by molybdenum atoms: A density functional theory study of the crossing seams of the potential energy surfaces. Organometallics 2008, 27 (2), 181–188.

11. Foley, N.A., Ke, Zhuofeng, Gunnoe, T.B., Cundari, T.R., & Petersen, J.L., Aromatic C-H activation and catalytic hydrophenylation of ethylene by TpRu{P(OCH2)(3)CEt}(NCMe)Ph. Organometallics 2008, 27 (13), 3007–3017.

10. Lin, X.F., Zhao, C.Y., Che, C.M., Ke, Zhuofeng, & Phillips, D.L., A DFT study on the mechanism of Rh-2(II,II)-catalyzed intramolecular amidation of carbamates. Chem. Asian J. 2007, 2 (9), 1101–1108.

9. Ke, Zhuofeng, Zhou, Y.B., Gao, H., Zhao, C.Y., & Phillips, D.L., On the mechanism and stereochemistry of chiral lithium-carbenoid-promoted cyclopropanation reactions. Chem. Eur. J. 2007, 13 (23), 6724–6731.

8. Ke, Zhuofeng, Zhao, C.Y., & Phillips, D.L., Methylene transfer or carbometalation? A theoretical study to determine the mechanism of lithium carbenoid-promoted cyclopropanation reactions in aggregation and solvation states. J. Org. Chem. 2007, 72 (3), 848–860.

7. Gao, H.Y., Ke, Zhuofeng, Pei, L.X., Song, K.M., & Wu, Q., Drastic ligand electronic effect on anilido-imino nickel catalysts toward ethylene polymerization. Polymer 2007, 48 (25), 7249–7254.

6. Fang, R., Ke, Zhuofeng, Shen, Y., Zhao, C.Y., & Phillips, D.L., Concurrent cyclopropanation by carbenes and carbanions? A density functional theory study on the reaction pathways. J. Org. Chem. 2007, 72 (14), 5139–5145.

5. Zhou, Y.B., Ke, Zhuofeng, & Zhao, C.Y., A theoretical study on the mechanism of ruthenium(II)-catalyzed reaction of organic azide with alkyne. Acta Chim. Sin. 2006, 64 (20), 2071–2078.

4. Zhang, J.K., Ke, Zhuofeng, Bao, F., Long, J.M., Gao, H.Y., Zhu, F.M., & Wu, Q., Ethylene polymerization and oligomerization catalyzed by bulky beta-diketiminato Ni(II) and beta-diimine Ni(II) complexes/methylaluminoxane systems. J. Mol. Catal. A: Chem 2006, 249 (1-2), 31–39.

3. Ye, G.D., Ke, Zhuofeng, Yan, J.W., Zhao, T.Y., Zeng, Z.H., & Chen, Y.L., Low VOC bifunctional photoinitiator based on alpha-hydroxyalkylphenone structure. Polymer 2006, 47 (13), 4603–4612.

2. Li, Z.H., Ke, Zhuofeng, Zhao, C.Y., Geng, Z.Y., Wang, Y.C., & Phillips, D.L., A density functional theory study of aluminum carbenoid (CH3)(2)AlCH2X (X = Cl, Br, I) promoted cyclopropanation reactions compared to IMCH2I (M = Li, Sm, Zn) carbenoids. Organometallics 2006, 25 (15), 3735–3742.

1. Zhang, J.K., Gao, H.Y., Ke, Zhuofeng, Bao, F., Zhu, F.M., & Wu, Q., Investigation of 1-hexene isomerization and oligomerization catalyzed with beta-diketiminato Ni(II) bromide complexes/methylaluminoxane system. J. Mol. Catal. A: Chem 2006, 231 (1-2), 27–34

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