程度

个人基本简介: 

姓名:程度

中山大学,材料科学与工程学院,副教授, 博士生导师

电话:020-84112105

邮箱:chengdu@mail.sysu.edu.cn

主要经历: 

2012/02-至   今   中山大学化学院,材料科学与工程学院

2016/12-2017/12, 美国哥伦比亚大学生物医学工程系,访问学者

2008/12-2012/01, 中山大学化学与化工学院,博士后

2003 /07-2008/11,   广州拓谱基因技术有限公司,副研究员

1999/09-2003/06,  中山大学,生命科学学院,博士

学科方向: 

1. 智能控释多功能载体及其用于传输药物和诊断探针的研究

2. 纳米材料与生物技术的交叉研究

主讲课程

本科生课程:生物医用材料(负责人),基础化学实验(无机I), 基础化学实验(无机II)  基础化学实验(有机I),基础化学实验(有机II)。

研究生课程:智能材料(负责人),生物材料研究进展(负责人)。

代表论著: 

从事智能纳米材料及其在疾病治疗及诊断中的应用研究。在Nature MedicineAdvanced MaterialsBiomaterialsSmallNanoscale等国际权威期刊上发表研究论文40余篇。主持国家重点研发计划政府间国际合作项目、国家自然科学基金项目、粤港联合创新和省部产学研项目10余项。

主要科研项目:

(1) 国家重点研发计划政府间国际合作项目,名称:基于多功能支架材料的基因编辑技术,批准号:S2016G3030, 131.40万,负责人

(2) 国家自然科学基金-广东联合基金重点项目,“作用于肿瘤微环境的非细胞毒化物型高效抗肿瘤高分子的设计”,批准号:U1501243, 2016年1月至2019年12月,270万,共同负责人(Co-PI)。

(3) 国家自然科学基金面上项目“具有体内长循环性能的pH及还原双重敏感核酸载体的制备及其在肿瘤治疗中的应用”,批准号:51373203,2014年1月至2017年12月,85万元,负责人。

(4) 国家自然科学基金面上项目“环境双响应性靶向控释载体联合传输化疗药和纳米金治疗肿瘤”,批准号:21174166,2012年1月至2015年12月,62万元,负责。

(5) 国家自然科学基金面上项目,“兼具智能药物释放及肿瘤靶向性的MRI可见聚合物纳米载体研究”,批准号:20974129,33万元,2010年1月至2012年12月,负责人。

(6) 粤港联合创新,“基于CRISPR技术联合输送多因子协同调控免疫防治流感”,批准号:2016A050503026,2016 年1 月至2018 年12 月, 100万,负责人。

(7) 广州市产学研协同创新重大专项,“基于智能纳米材料和基因编辑技术改进CAR-T抗肿瘤免疫治疗”,批准号:201704030123,2017年4月至2019年4月, 100万,负责人。

 

代表性论文(*通讯作者和第一作者):

Guoyong Zhou, Hong Xiao, Xiaoxia Li, Yi Huang, Wei Song, Liang Song, Meiwan Chen, Du Cheng*, and Xintao Shuai*. Gold nanocage decorated pH-sensitive micelle for highly effective photothermo-chemotherapy and photoacoustic imaging. Acta Biomaterialia, 2017, doi.org/10.1016/j.actbio.2017.10.018.

Lu Wang, Yuanyuan Yuan, Shudong Lin, Jinsheng Huang, Jian Dai, Qing Jiang, Du Cheng*, Xintao Shuai*. Photothermo-chemotherapy of cancer employing drug leakage-free gold nanoshells. Biomaterials, 2016, 78: 40-49.

Lu Zhang, Hong Xiao, Jingguo Li, Du Cheng*, Xintao Shuai*. Co-delivery of doxorubicin and arsenite with reduction and pH dual-sensitive vesicle for synergistic cancer therapy. Nanoscale, 2016, 8(25): 12608-12617.

Junwei Li, Hong Xiao, Soon Joon Yoon, Chengbo Liu, Drew Matsuura, Wanyi Tai, Liang Song, Matthew O'Donnell*, Du Cheng*, Xiaohu Gao*. Functional Photoacoustic Imaging of Gastric Acid Secretion Using pH‐Responsive Polyaniline Nanoprobes. Small, 2016, 12(34): 4690-4696.

Guoyong Zhou, Yongmin Xu, Meiwan Chen, Du Cheng*, Xintao Shuai*. Tumor-penetrating peptide modified and pH-sensitive polyplexes for tumor targeted siRNA delivery. Polymer Chemistry, 2016, 7(23): 3857-3863.

Jianbing Huang, Hui Liang, Du Cheng*, Jiang Lu*. Polypeptide–poly (ethylene glycol) miktoarm star copolymers with a fluorescently labeled core: synthesis, delivery and imaging of siRNA. Polymer Chemistry, 2016, 7(9): 1792-1802.

Li Zhanrong, Jingguo Li*, Jinsheng Huang, Junjie Zhang, Du Cheng*, and Xintao Shuai. Synthesis and Characterization of pH‐Responsive Copolypeptides Vesicles for siRNA and Chemotherapeutic Drug Co-Delivery. Macromolecular Bioscience, 2015, 15(11): 1497-1506.

Jin Wang, Linglan Ren, Jingguo Li, Jinsheng Huang, Du Cheng*, and Xintao Shuai*, Effective siRNA therapy of hepatoma mediated by a nonviral vector with MRI-visibility and biodegradability, RSC Advance, 2015, 5, 21103 -21111.

Wang Wei-juan, Xiao Hong, Cheng Du*, and Shuai Xintao. A Theranostic Nanosystem Based on Polyaspartamide Derivative to Co-deliver siRNA and MR Contrast Imaging Agent. Acta Polymercia Sinica, 2015, 4:484-492.

Zuoquan Zhang, Qiquan Sun, Jinglian Zhong, Qihua Yang, Hao Li, Du Cheng*, Biling Liang, and Xintao Shuai, Magnetic Resonance Imaging-Visible and pH-Sensitive Polymeric Micelles for Tumor Targeted Drug Delivery. Journal of Biomedical Nanotechnology, 2014, 10: 216-226.

Jingguo Li, Du Cheng*, Tinghui Yin, Weicai Chen, Yujie Lin, Jifeng Chen, Ruitang Li, Xintao Shuai*, Copolymer of poly (ethylene glycol) and poly (L-lysine) grafting polyethylenimine through reducible disulfide linkage for siRNA delivery. Nanoscale, 2014, 6, 1732-1740.

Faming Gong, Zuoquan Zhang, Xiaodong Chen, Lu Zhang, Xingsu Yu, Qihua Yang, Xintao Shuai, Biling Liang*, and Du Cheng*, A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer. Chinese Journal of Polymer Science, 2014, 32, 321-332.

Xiang Guanghua., Guobin Hong, Yong Wang, Du Cheng*, Jingxing Zhou*, Xintao Shuai, Effect of PEG-PDLLA polymeric nanovesicles loaded with doxorubicin and hematoporphyrin monomethyl ether on human hepatocellular carcinoma HepG2 cells in vitro. International journal of nanomedicine, 2013, 8, 4613-4622.

Liu, Yunyun, Zhonglin Liu*, Yong Wang, Yan-Ran Liang, Xiaojun Wen, Jingyang Hu, Xingyi Yang, Jun Liu, Songhua Xiao, and Du Cheng*. Investigation of the performance of PEG–PEI/ROCK-II-siRNA complexes for Alzheimer’s disease in vitro. Brain Research 2013, 1490, 43-51.

Du Cheng, Nuo Cao, Jifeng Chen, Xingsu Yu, Xintao Shuai*. Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat. Biomaterials, 2012, 33(4): 1170-1179.

Weiwei Wang#, Du Cheng#, Faming Gong, Xiangmin Miao, Xintao Shuai*. Design of multifunctional micelle for tumor-targeted intracellular drug release and fluorescent imaging. Advanced Materials, 2012, 24(1): 115-120.

Du Cheng, Guobin Hong, Weiwei Wang, Renxu Yuan, Hua Ai, Jun Shen, Biling Liang, and Xintao Shuai*. Nonclustered magnetite nanoparticle encapsulted biodegradable polymeric micelles with ebhanced properties for in vivo tumor imaging. Journal of Materials Chemistry, 2011, 21, 4796-4804. (Cover article, highlighted in RSC World Chemistry)

Nuo Cao†, Du Cheng(共同第一作者), Seyin Zou, Hua Ai, Jinming Gao, and Xintao Shuai*. The synergistic effect of hierarchical assemblies of siRNA and chemotherapeutic drugs co-delivered into hepatic cancer cells. Biomaterials, 2011, 32, 2222-2232.

Qiquan Sun†, Du Cheng(共同第一作者), Xingsu Yu, Zuoquan Zhang, Jian Dai, Hao Li, Biling Liang, and Xintao Shuai*. A pH-sensitive Polymeric Nanovesicle Based on Biodegradable Poly(ethylene glycol)-b-poly(2-(diisopropylamino)ethyl aspartate) as a MRI-visible Drug Delivery System. Journal of Materials Chemistry, 2011, 21, 15316-5326.

Baojian Li†(中山大学), Qingquan Tang†, Du Cheng†(共同第一), Chuan Qin, Frank Y Xie, Qiang Wei, Jun Xu, Yijia Liu, Bo-jian Zheng5, Martin C Woodle, Nanshan Zhong, Patrick Y Lu. Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nature medicine, 2005, 11(9): 944-951.

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