刘利新

个人基本简介: 

职称:副教授,博士生导师

学位:博士

电子邮件:liulixin@mail.sysu.edu.cn

科研项目

主持国家自然科学基金(21875290,30670889);广东省科技厅社会发展领域项目;中国科学院重要方向性项目集群项目子课题:新型艾滋病和病毒性肝炎灵长类动物模型的创建(KSCX2-EW-R-13);中国科学院知识创新工程重要方向项目(生命科学领域“十二五”基础前沿专项)子课题:微流控纳米及顺磁生物新技术研究(KSCX2-EW-J-29);“十二五”国家科技支撑计划课题:“亚健康状态的评价指标及城市人口亚健康监测网络与数据库的建立”子课题:亚健康状态产生的分子学机制研究;省纳米创新团队项目主要成员,国家自然科学资金重点项目主要成员。

主要经历: 

教育经历

1994年于吉林医学院预防医学专业毕业,获医学学士学位

1999年于中国科学院微生物研究所研究生毕业,获理学硕士学位

2002年于德国杜塞尔多夫大学儿童血液肿瘤研究所,获得医学博士学位

工作经历

2002 -2005 中国科学院微生物研究所工作     科研工作 助理研究员

2005-2007  中国科学院大学生命科学院     教学与科研工作 讲师

2007-2014  中国科学院大学生命科学院     教学与科研工作 副教授

2014-至今  中山大学材料科学与工程学院     教学与科研工作 副教授

学科方向: 

纳米材料做为疫苗佐剂及载体的研究,纳米材料在自身免疫性疾病治疗中应用研究。

荣誉获奖: 

2006-2007学年,《分子病毒学》获得中国科学院研究生院优秀课程

2007-2008学年,《分子病毒学》获得中国科学院研究生院优良课程

2008学期,《分子病毒学》获得中国科学院教学成果二等奖,排名第一

代表论著: 
  1. Bo Peng, Huiyi Liang, Yuyan Li, Cong Dong, Jun Shen, Hai-Quan Mao, Kam W. Leong, Yongming Chen, and Liu, L.X.*Tuned Cationic Dendronized Polymer: Molecular Scavenger for Rheumatoid Arthritis Treatment, Angew. Chem. Int. Ed. 2019, 58:4254-4259.
  2. Huiyi Liang, Bo Peng, Cong Dong, Liu, L.X.*, Jiaji Mao, Song Wei, Xinlu Wang, Hanshi Xu, Jun Shen*, Hai-Quan Mao, Xiaohu Gao, Kam W. Leong*, Yongming Chen*, Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation, Nature Communication, 2018, 9:4291-4305.
  3. Qiao, D.D.; Liu, L.X.*; Chen, Y.; Xue, C.B.; Gao, Q.; Mao, H.Q.*; Leong, K.W.*; Chen, Y.M., Potency of a Scalable Nanoparticulate Subunit Vaccine. Nano Letters. 2018, 18 (5), 3007-3016.
  4. Li, Z.Y; Zhou, F.; Li, Z.Y.; Lin, S.Y.; Chen, L.; Liu, L.X.; Chen, Y.M.*, Hydrogel Cross-Linked with Dynamic Covalent Bonding and Micellization for Promoting Burn Wound Healing. ACS applied materials & interfaces. 2018, 10 (30), 25194-25202.
  5. Chen, Y.; Zhou, H.B.; Sun, Z.Y.; Li, H.A.; Huang, H.U.; Liu, L.X.*; Chen, Y.M.*, Shell of amphiphilic molecular bottlebrush matters as unimolecular micelle. Polymer. 2018, 149, 316-324.
  6. He, Z.Y.; Liu, Z.J.; Tian, H.K.; Hu, Y.Z.; Liu, LX..; Leong, K.W.*; Mao, H. Q.*; Chen, Y.M.*, Scalable Production of Core-Shell Nanoparticles by Flash Nanocomplexation to Enhance Mucosal Transport for Oral Delivery of Insulin. Nanoscale. 2018, 10 (7), 3307-3319.
  7. Plummer, C. M.; Zhou, H.B.; Zhu, W.; Huang, H.H.; Liu, L.X.; Chen, Y.M.*, Mild Halogenation of Polyolefins Using An N-haloamide Reagent. Polymer Chemistry 2018, 9 (11), 1309-1317.
  8. Hu, Z.T.; Chen, Y.; Huang, H.H.; Liu, L.X.; Chen, Y.M.*, Well-Defined Poly(α-amino-δ-valerolactone) via Living Ring-Opening Polymerization. Macromolecules. 2018, 51 (7), 2526-2532.
  9. Zeng, Z.P.; Zhao, P.F.; Liu, L.X.*; Gao, X.H.; Mao, H.Q.; Chen, Y.M.*, Lipid Stabilized Solid Drug Nanoparticles for Targeted Chemotherapy. ACS applied materials & interfaces. 2018, 10 (30), 24969-24974.
  10. Li, H.A.; Liu, H.; Nie, T.Q.; Chen, Y.; Wang, Z.Y.*; Huang, H.H.; Liu, L.X.*; Chen, Y.M.*, Molecular Bottlebrush as A Unimolecular Vehicle with Tunable Shape for Photothermal Cancer Therapy. Biomaterials. 2018, 178, 620-629.
  11. Wu, X.L.; Wu, Y.D.; Wang, Z.Y.; Liu, L.X. *; Sun, C.X.; Chen, Y.M.; Wang, C.*, A Cascade-Targeting Nanocapsule for Enhanced Photothermal Tumor Therapy with Aid of Autophagy Inhibition. Advanced Healthcare Materials. 2018, 7 (11), e1800121.
  12. Chu, Y.H.; Li, H.A.; Huang, H.H.; Zhou, H.B.; Chen, Y.; Andreas, B.; Liu, L.X.*; Chen, Y.M.*, Uni-Molecular Nanoparticles of Poly(2-Oxazoline) Showing Tunable Thermoresponsive Behaviors. Journal of Polymer Science Part A-Polymer Chemistry. 2018, 56(2), 174-183.
  13. He, Z.Y.; Santos, J.L.; Tian, H.K.; Huang, H.H.; Hu, Y.Z.; Liu, L.X.; Leong, K.W.*; Chen, Y.M.*; Mao, H.Q.*, Scalable Fabrication of Size-Controlled Chitosan Nanoparticles for Oral Delivery of Insulin. Biomaterials. 2017, 130, 28-41.
  14. Peng, B.; Lai, X.Y.; Chen, L.; Lin, X.M.; Sun, C.X.; Liu, L.X.*; Qi, S.H.; Chen, Y.M.*; Leong, K.W.*, Scarless Wound Closure by a Mussel-Inspired Poly(amidoamine) Tissue Adhesive with Tunable Degradability. ACS Omega. 2017, 2(9), 6053−6062.
  15. Sun, Z.Y.; Huang, H.H.; Li, L.; Liu, L.X.*; Chen, Y.M.*, Polythioamides of High Refractive Index by Direct Polymerization of Aliphatic Primary Diamines in the Presence of Elemental Sulfu. Macromolecules. 2017, 50(21), 8505-8511.
  16. Yan, Y.C.; Huang, H.H.*; Zhu, W.; Liu, L.X.; Zhang, K.; Chen, Y.M.*, Synthesis of Amphiphilic Polymer Brushes with Mixed Side Chains and Their Emulsifying Function. Acta Polymerica Sinica. 2017, 9, 1531-1537.
  17. Xing Y.X.; Chu Q.Y.; Feng R.; Wang W.; Liu L.X.*; Lu Z.B*., hCLP46 Increases Smad3 Protein Stability via Inhibiting Its Ubiquitin-Proteasomal Degradation. Protein & Cell. 2015, 6(10), 767-770.
  18. Yang, G.L.; Zhang, R.; Huang, H.H.*; Liu, L.X.; Wang, L.*; Chen, Y.M.*, Synthesis of Novel Biobased Polyimides Derived from Isomannide with Good Optical Transparency, Solubility and Thermal Stability. RSC Advances. 2015, 5 (83), 67574-67582.
  19. Bai, R.; Zhang, X.J.; Li, Y.L.; Liu, J.P.; Zhang, H.B.; Xiao, W.L.; Pu, J.X.; Sun, H.D.; Zheng, Y.T.*; Liu, L.X*;., SJP-L-5, A Novel Small-Molecule Compound, Inhibits HIV-1 Infection by Blocking Viral DNA Nuclear Entry. BMC Microbiology. 2015, 15, 274-287.
  20. Zhang S.; Bai R.; Feng R.; Zhang H.; Liu L.X.* Detection and Evolutionary Analysis of Picobirnaviruses in Treated Wastewater. Microb Biotechnol. 2015, 8(3), 474-482.
  21. Wang, J.; Zhu, W.*; Liu, L.X*.; Chen, Y.M*.; Wang, C., Synthesis and Cellular Internalization of Spindle Hematite/Polymer Hybrid Nanoparticles. ACS Applied Materials & Interfaces. 2015, 7(9), 5454-5461.
  22. Wang, J.; Liu, L.X.*; Zhu, W.; Chen, Y.M.*; Wang, C.*, Cancer Cell Uptake of Polymer Hydrogel Nanotubes. J. Biomed. Nanotechnol. 2014, 10, 3329-3336.
  23. Zhu, W.; Peng, B.; Wang, J.; Zhang, K.; Liu, L. X.*; Chen, Y. M.* Bamboo Leaf-Like Micro-Nano Sheets Self-Assembled by Block Copolymers as Wafers for Cells. acromolecular Bioscience. 2014, 14, 1764-70.
  24. Chu, Q.; Liu, L.X.*; Wang, W*., Overexpression of hCLP46 Enhances Notch Activation and Regulates Cell Proliferation in A Cell Type-Dependent Manner. Cell Prolif. 2013, 46 (3), 254-62.
  25. Cui, Y.; Wu, Y. S.; Liu, Y.; Yang, G. M.; Liu, L. X.; Fu, H. B.; Li, Z, B.; Wang, S.; Wang, Z. H.*; Chen, Y. M.*, PEGylated Nanoparticles of Diperylene Bisimides with High Efficiency of O-1(2) Generation. Dyes and Pigments. 2013, 97129-33.
  26. Zhao, P.; Yan, Y. C.; Feng, X. Q.; Liu, L.X.*; Wang, C.; Chen, Y. M.*, Highly Efficient Synthesis of Polymer Brushes with PEO and PCL as Side Chains via Click Chemistry. Polymer, 2012, 53, 1992-2000.
  27. Zhao, P.; Liu, L.X.*; Feng, X. Q.; Wang, C.*; Shuai, X. T.; Chen, Y. M.*, Molecular Nanoworm with PCL Core and PEO Shell as Non-Spherical Carrier for Drug Delivery. Macromol. Rapid Commun. 2012,33, 1351-5
  28. Zhu, W.; Li, Y. L.; Liu, L X.*; Chen, Y. M.*; Xi, F., Supramolecular Hydrogels as A Universal Scaffold for Stepwise Delivering Dox and Dox/cisplatin Loaded Block Copolymer Micelles. International Journal of Pharmaceutics. 2012, 437, 9-11.
  29. Zhu, W.; Li, Y. L.; Liu, L.X.;* Chen, Y. M.;* Wang, C.; Xi, F., Biamphiphilic Triblock Copolymer Micelles as A Multifunctional Platform for Anticancer Drug Delivery. J. Biomed. Mater. Res. Part A. 96A .2011, 330-340.
  30. Zhang, W. L.; Li, Y. L.; Liu, L.X.*; Sun, Q.; Shuai, X. T.; Zhu, W.; Chen, Y. M.*, Amphiphilic Toothbrush-like Copolymers Based on Poly(ethylene glycol) and Poly(ε-caprolactone) as Drug Carriers with Enhanced Properties. Biomacromolecules. 2010, 11, 1331-1338.
  31. Zhu, W.; Li, Y. L; Liu, L.X.*; Zhang, W.; Chen, Y. M.*; Xi, F., Supramolecular Hydrogels from Cisplatin-Loaded Block Copolymer Nanoparticles and α-Cyclodextrins with a Stepwise Delivery Property. Biomacromolecules. 2010, 11, 3086-3092.
  32. Li, Z.Q.; Liu, L.X.; Lv, F.X.; Ma, J.; Gao, G.X.*, Fusing ZAP to HIV RNA Binding Proteins to Inhibit HIV. Progress in Biochemistry and Biophysics. 2007, 34, 50-56.
  33. Ye, J.; Liu, L.X.; Gao, G.X.;* Fang, R.X.* Inhibition of SARS by Small Interfering RNAs Targeting the Leader RNA. Progress in Biochemistry and Biophysics 2007, 34, 1092-1100. (共为第一作者)
  34. Borrowski, A.; Dirkson, U.*; Liu, L.X. Shi, R. L; Goebal, U. Structure and Function of ETAA-16: A Novel Cell Surface Antigen in Ewing Tumors. Cancer Immunology Immunotherapy. 2006, 55, 363-374.
  35. Liu, L.X.; Chen, G.F.; Ji, X.; Gao, G.X.* ZAP is a CRM1 dependent protein. Biochemical and Biophysical Research Communications. 2004, 321, 517-523.
  36. Lan, J. ; Song, M.S. ; Pan, C.H. ; Zhuang, G.Q. ; Wang, Y.X. ; Ma, W.Z. ; Chu, Q.Y. ; Lai, Q.X. ; Xu, F. ; Li, Y.L. ; Liu, L.X. ; Wang,W., Association between Dopaminergic Genes (SLC6A3 and DRD2) and Stuttering among Han Chinese. Journal of Human Genetics (Nature Publishing Group). 2009,54, 457-460.
  37. Ma, W.Z. ; Du, J. ; Chu, Q.Y. ; Wang, Y.X. ; Liu, L.X. ; Song, M.S. ; Wang, W., hCLP46 Regulates U937 Cell Proliferation via Notch Signaling Pathway. Biochemical and Biophysical Research Communication. 2011,408, 84-88.
  38. Wang, Y.X.; Chang, N.B.; Zhang, T.; Liu, H.; Ma, W.Z.; Chu, Q.Y.; Lai, Q.X.; Liu, L.X.; Wang, W., Overexpression of Human CAP10-like Protein 46 KD in T-acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia. Genetic Testing and Molecular Biomarkers. 2010, 14, 127-33.
  39. Sheng A.; Lan J.; Wu H.; Lu J.; Wang Y.; Chu Q.; Jia Z.; Song M.; Liu L.X.; Wang W., A Clinical Case Control Study on the Association between Mannose-binding Lectin and Susceptibility to HIV-1 Infection among Northern Han Chinese population. International Journal of Immunogentics. Int J Immunogenet. 2010, 37, 445-54.
  40. 刘利新*,刘树峰等。人Dcp2(脱帽酶2)克隆表达、多克隆抗体的制备及其应用。《中国科学院研究生院学报》2007,24: 362-367。
  41. 张恬,王有信,王嵬,刘利新*。人CD34+干/祖细胞异常表达新基因hCLP46 的克隆,表达与功能分析。《中国科学院研究生院学报》2007,4:520-52
  42. 盛艾娟,刘利新,吴昊,王友信,彭晓霞,王嵬。中国北方汉族人群MBL与HIV易感性的研究。《南方医科大学学报》2008,4:567-571。
  43. 盛艾娟;吴昊;兰洁;路甲鹏;王友信;宋曼殳;武晶晶;刘利新;王嵬, 甘露糖结合凝集素与人类免疫缺陷病毒感染的关联性研究(英文), 中国病毒病杂志, 02期, pp 92-98, 2011.
  44. 张文娟,杜杰,常乃柏,张恬,王嵬,刘利新*。酵母双杂交技术筛选与hCLP46蛋白相互作用的蛋白。《中国生物工程杂志》2008,6:23-27。
  45. 李艳丽,郑友唐,王嵬,刘利新﹡。利用假病毒技术研究抗HIV-1药物的作用机制 。《微生物学通报》,2011,10:1507-1517。
  46. 徐峰,穆昕,王嵬,刘利新﹡ 。串联亲和纯化技术筛选hCLP46的相互作用蛋白 。《中国科学院研究生院学报》2011,2:210-217(通讯作者)。
  47. 冯晓琴,徐峰,王嵬,刘利新﹡。通过对免疫共沉淀技术优化验证蛋白质弱相互作用的研究。《中国科学院研究生院学报》,2013,30:18-23。

会议获奖

Li, Y. L.; Gao, G. X.; Zheng, Y. T.; Liu, L. X.;* A simple method for exploring the mechanisms for anti-HIV compounds. Abstract of 4th Ditan International Conference on Infectious Diseases. 2010 (获得大会议AGD奖).

会议论文

  1. Ru Bai, Shiwei Zhang, Hongxun Zhang, Lixin Liu. Ultracentrifugation as a direct method to concentrate viruses in sewage, 中国生态学学会微生物生态专业委员会2013年年会会议论文集,P71,成都,2013.11.15-18
  2. Shiwei Zhang, Ru Bai, Lixin Liu. Treated Wastewater from Poultry Farms Harbours Diverse Picobirnavirus Population,中国生态学学会微生物生态专业委员会2013年年会会议论文集,P70,成都,2013.11.15-18
  3. 杨金龙,张士伟,张洪勋,刘利新。玻璃棉滤器浓缩水体病毒方法的建立与优化。中国生态学学会微生物生态专业委员会2013年年会会议论文集,P86,成都,2013.11.15-18

 

  1. Therapeutic protein-loaded nanoparticle and method for preparing the same,申请号:PCT/US17/14080.
  2. 孙成新、刘利新、陈永明。一种鼠尾静脉精准注射仪(ZL201621037464.0)
  3. 刘利新、高光侠。抗HIV病毒的多肽及其编码基因与应用(200510114234.X).

参编教材

《抗病毒天然免疫》(舒红兵主编)第三章内源性免疫:宿主限制因子。科学出版社,2009。

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